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KMID : 0376020000200000009
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Rehabilitation Research
2000 Volume.20 No. 0 p.9 ~ p.24
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Effect of Deferoxamine on Acute Peripheral Nerve Compression
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안미경/Mi Kyung Ahn
이명흔/조영진/Myung Heun Lee/Young Jin Cho
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Abstract
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The effecrs of deferoxamine, an antioxidant, on recovery from ischemia/reperfusion injury after acute nerve compression were investigated with electrophysiological method. The sciatic nerve of male Spraque-Dawley rats, 180-220g, were subjected to 3 minutes of compression with Kelly covered with silastic tube. The control group were injected intraperitoneal saline solution at the time of decompression. The therapeutic group were injected intraperitoneal deferoxamine(50㎎ per kilogram) at the time of removal of the compression. The motor nerve conduction studies and needle EMG studies were performed. The compound muscle action potentials (CMAP) were obtained with distal & proximal stimulation to injured site. The latencies of CMAP were not
significantly diffenent between two groups (p>0.05), eventhough the latencies of CMAP in therapeutic group showed shorter than those in control group. The amplitude change of CMAP between two group were not different. The results doesn't confirm that the treatment of compressed peripheral nerve with deferoxamine at the time of surgical compression reduced ischemia / reperfusion injury . In this study, the peripheral nerve lesion was not pure ischemic origin, but associated with mechanical distortion and serve axonal injury due to crushing of nerve. The effect of deferoxamine in compressed nerve lesion with mechanical distortion is not proved by elecrtophysiologic method and needed further investigation.
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